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Clinical features and imaging manifestations of retinoblastoma with hepatic metastasis
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  • Huali Gu,
  • Dongsheng Huang,
  • Zhuo Wang,
  • Yi Zhang,
  • ling Zhang,
  • Hui-Min Hu,
  • Pinwei Zhang,
  • Yan Zhou,
  • You Yi,
  • Siyu Han
Huali Gu
Beijing Tongren Hospital

Corresponding Author:hlgu0217@163.com

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Dongsheng Huang
Beijing Tongren Hospital
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Zhuo Wang
Beijing Tongren Hospital
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Yi Zhang
Beijing Tongren Hospital
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ling Zhang
Beijing Tongren Hospital
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Hui-Min Hu
Beijing Tongren Hospital
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Pinwei Zhang
Beijing Tongren Hospital
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Yan Zhou
Beijing Tongren Hospital
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You Yi
Beijing Tongren Hospital
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Siyu Han
Beijing Tongren Hospital
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Abstract

Background: Hepatic metastasis from retinoblastoma (RB) is rare. We evaluated clinical features, imaging manifestations, treatment, and prognosis in these patients. Procedure: Clinical data of five patients diagnosed with hepatic metastases of RB at the Department of Pediatrics in Beijing Tongren Hospital between January 2009 and January 2019 were analyzed retrospectively. Results: Two patients had bilateral lesions, while three had unilateral lesions. Among the seven eyes with lesions, six and one were classified as stage E and C, respectively (International Integrated Reporting Council staging). On computed tomography (CT), low-density foci were observed (three, multiple foci and two, single foci). After chemotherapy, tumor regression was observed in four patients, while there was no response in one patient. Three patients who underwent enucleation were at high risk for extensive choroidal invasion. All patients had severe disease with multiple system involvement, including central nervous system (CNS) and bone metastases. Neuron-specific enolase (NSE) and lactate dehydrogenase (LDH) levels were significantly elevated in all patients; after treatment, they decreased in four patients and remained unchanged in one patient with end-stage disease. Two patients died, with survival durations of 1 and 3 months following the diagnosis of hepatic metastasis. Three patients survived and continued treatment. Conclusion: Hepatic metastasis from RB is rare and usually occurs with CNS and bone metastases. On CT, hepatic foci could be indicated by low-density lesions with calcification. Chemotherapy could be effective for hepatic metastases. The prognosis of these patients is poor; however, hepatic metastasis is not a direct cause of death.
29 Dec 2020Submission Checks Completed
29 Dec 2020Assigned to Editor
29 Dec 2020Submitted to Pediatric Blood & Cancer
30 Dec 2020Reviewer(s) Assigned
14 Jan 2021Review(s) Completed, Editorial Evaluation Pending
15 Jan 2021Editorial Decision: Revise Major
24 Jan 20211st Revision Received
24 Jan 2021Submission Checks Completed
24 Jan 2021Assigned to Editor
25 Jan 2021Reviewer(s) Assigned
29 Jan 2021Review(s) Completed, Editorial Evaluation Pending
30 Jan 2021Editorial Decision: Accept
Oct 2021Published in Pediatric Blood & Cancer volume 68 issue 10. 10.1002/pbc.28959