3.3 I2-IR ligand LSL60101 and donepezil ameliorate social deficits presented by 5XFAD mice.
To evaluate the effect of treatments on social behaviour, the mice were subjected to the TCT. No differences in the number of the entries to each chamber were determined in the habituation phase in any tested group (Figure 2g). In contrary mice spent more time in the intruder’s chamber during the test phase in all experimental conditions (Figure 2h). When the social interaction was evaluated, 5XFAD mice spent significantly less time interacting with the intruder when compared to WT healthy control. All treatments improved social impairments in 5XFAD treated groups by increasing the time of interaction compared to the 5XFAD controls, but only 5XFAD treated with donepezil reached significance (Figure 2i), whereas for LSL60101 p<0.06 was calculated. WT treated mice presented no differences compared to WT controls.