3.5 I2-IR ligand LSL60101 and combination with donepezil reduce Tau hyperphosphorylation in 5XFAD mice
Tau hyperphosphorylation, another major hallmark of AD, was evaluated in the hippocampus of the 5XFAD mice. I2-IR ligand LSL60101 and the co-treatment donepezil/LSL60101 decreased the Tau phosphorylation at the Ser404 and Ser396, diminutions that reached significance for the donepezil/LSL60101 treated 5XFAD mice. Of note, significant differences in p-Tau levels were found as well between the donepezil/LSL60101 5XFAD treated mice, and the donepezil or LSL60101 treated ones (Figure 3e, 3f).