3.5 I2-IR ligand LSL60101 and combination with donepezil reduce
Tau hyperphosphorylation in 5XFAD mice
Tau hyperphosphorylation, another major hallmark of AD, was evaluated in
the hippocampus of the 5XFAD mice. I2-IR ligand LSL60101 and the
co-treatment donepezil/LSL60101 decreased the Tau phosphorylation at the
Ser404 and Ser396, diminutions that reached significance for the
donepezil/LSL60101 treated 5XFAD mice. Of note, significant differences
in p-Tau levels were found as well between the donepezil/LSL60101 5XFAD
treated mice, and the donepezil or LSL60101 treated ones (Figure 3e,
3f).