Statistical data analysis
The data are presented as mean ± standard deviation or median [1st–3rd quartile] for continuous variables as appropriate, and as frequency (%) for categorical variables. Variables were compared with Student’s t-test or Mann-Whitney test. Categorical data were compared with the χ2 test or Fisher’s exact test. All statistical analyses were performed with JMP® 14 (SAS Institute Inc., Cary, NC, USA). In all analyses, a two-tailed p-value < 0.05 was considered to indicate statistical significance.