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Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID-19
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  • Şahin Çolak,
  • burcu genç yavuz,
  • Mürsel Yavuz,
  • Burak Özçelik,
  • Metin Öner,
  • Asu Özgültekin,
  • Seniha Şenbayrak
Şahin Çolak
University of Health Sciences Haydarpasa Numune Training And Research Hospital

Corresponding Author:dr.sahincolak@gmail.com

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burcu genç yavuz
University of Health Sciences, Haydarpasa Numune Training and Research Center
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Mürsel Yavuz
Kosuyolu Rezonans Clinic
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Burak Özçelik
University of Health Sciences, Haydarpasa Numune Training and Research Hospital
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Metin Öner
University of Health Sciences, Haydarpasa Numune Training and Research Hospital
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Asu Özgültekin
University of Health Sciences, Haydarpasa Numune Training and Research Hospital
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Seniha Şenbayrak
Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Haydarpasa Numune Training and Research Hospital
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Abstract

Aim In this study, we aimed to investigate the effectiveness of ozone therapy, which is one of the integrative medicine applications that has been used safely for many years, on the prevalence of mortality in patients receiving COVID-19 treatment. Methods This was a prospective, controlled study conducted on patients with COVID-19 who were hospitalized in Health Sciences University, Haydarpasa Numune Training and Research Hospital. In this study, 55 patients were included. The patients were divided into two groups as the ozone group and the control group. Ozone therapy (major autohemotherapy) was applied to 37 patients who were being treated with the appropriate COVID-19 treatment protocol determined by the infectious diseases committee of our hospital. The ozone treatment protocol consisted of seven sessions (1 session/day) of intravenous ozone administration, applied in a volume of 100 mL and a concentration of 30 μg/mL. Only the conventional COVID-19 treatment protocol was applied to 18 patients in the control group. Clinical follow-up was performed until the discharge of the patients from the hospital with successful treatment or until the mortality occurred. Factors affecting mortality were analyzed using univariate regression analysis. Results Intensive care unit (ICU) hospitalization was required in six of 37 patients who were treated with ozone (16.2%), while four of 18 patients in the control group required ICU treatment (22.2%) (p = 0.713). When the mortality rates between the two groups were compared, mortality was lower in the ozone group (p = 0.032). As a result of univariate logistic regression analysis performed to determine the factors affecting mortality, treatment without ozone therapy was determined as a risk factor for mortality (OR:0.149, 95%CI 0.026-0.863, p=0.034). Conclusion In this study, we demonstrated that administration of ozone therapy along with the conventional medical treatment in patients hospitalized for COVID-19 could reduce mortality.
02 Dec 2020Submitted to International Journal of Clinical Practice
12 Dec 2020Submission Checks Completed
12 Dec 2020Assigned to Editor
12 Dec 2020Reviewer(s) Assigned
20 Jan 2021Review(s) Completed, Editorial Evaluation Pending
08 Feb 20211st Revision Received
10 Feb 2021Submission Checks Completed
10 Feb 2021Assigned to Editor
10 Feb 2021Reviewer(s) Assigned
23 Mar 2021Review(s) Completed, Editorial Evaluation Pending
01 Apr 20212nd Revision Received
02 Apr 2021Submission Checks Completed
02 Apr 2021Assigned to Editor
08 Apr 2021Review(s) Completed, Editorial Evaluation Pending
03 May 2021Editorial Decision: Accept