Analyses at subsequently annotated LAPW sites during continuous RF delivery
All left-sided LAPW lesion sets and 6 of 8 right-sided LAPW lesion sets were completed during continuous, uninterrupted RF application; onset timing of transitions for annotated sites 2-to-3, 3-to-4 and 4-to-5 is shown in supplementary table 2. At the left-sided LAPW there was progressively greater difference in timing between annotated sites of transition with RMA “on” versus “off”, increasing from a median of 1.2s (IQR 0.4 – 5.0) at annotated site-2 onset, to a median of 14.6s (IQR 7.6 – 23.0) at annotated site-5 onset. Examples for one case are shown in supplementary figures 15-18. At the right-sided LAPW, there was no progressive in crease in difference between RMA “on” versus “off” annotation. However, 35% (95% CI 21-53) right-sided transitions occurred with intermittent catheter-tissue contact, whereas for left-sided sites this was only 3% (95% CI 0 – 17).