Heparin is used as a classic anticoagulant in clinic. In addition, with the ongoing pandemic and unknown challenges, the mechanism of action of heparin in antiviral and anti-inflammatory aspects has been constantly discovered and clarified. This also provides effective support for the treatment of COVID-19 in specific contexts. Most importantly, heparin may act as a multi-drug.

There is growing evidence that the clinical manifestations of COVID-19 are not just respiratory, but also gastrointestinal symptoms. The difference of organ infection should be considered. In addition, as a key molecule mediating viral infection of cells, angiotensin-converting enzyme 2 (ACE2) provides an important intervention means for the exploration of antivirus. This is particularly important as the pandemic intensifies.