parameter categories Grade 1&2 Grade 3&4 OR (95% CI)a p-value OR (95% CI)b p-value
age 822 (57.7) 603 (44.3) 1.02 (1.01–1.04) <0.001 1.02 (1.01–1.04) <0.001
antihypertensive treatment with β-blockers and/or ACEI no 603 (58.3) 432 (41.7) 1.00 0.29 1.00 0.70
yes 217 (55.9) 171 (44.1) 1.14 (0.89–1.46) 0.95 (0.72–1.24)
cardiovascular disease no 502 (59.4) 343 (40.6) 1.00 0.04 .. ..
yes 313 (54.8) 258 (45.2) 1.27 (1.01–1.60) ..
bee venom* no 488 (58.2) 350 (41.8) 1.00 0.50 .. ..
yes 298 (56.7) 228 (43.4) 0.92 (0.72–1.17) ..
tryptase*+ ≤ 11.4µg/L 672 (58.0) 487 (42.0) 1.00 <0.001 1.00 <0.001
> 11.4µg/L 46 (36.2) 81 (63.8) 2.37 (1.61–3.50) 2.43 (1.63–3.64)
verified mastocytosis* no 765 (58.3) 548 (41.7) 1.99 <0.001 .. ..
yes 11 (29.7) 26 (70.3) 3.73 (1.74–7.98) ..