Nickel allergy was detected in approximately 15% of the population. Despite this rate, very few patients developed symptoms related to nickel allergy after cardiac device insertion. In this case report, pericardial effusion due to nickel allergy that develops after the insertion of Atrial Septal Defect (ASD) device is described. The patient was discharged with ibuprofen. In some cases, dramatic conditions up to the tampon after effusion may develop. These patients responded to high-dose steroid; however, devastating side effects developed. However, more detailed and comprehensive advanced research is needed on this subject.