Any past TLOC event (N=3153) Unexplained syncope (n=466) Remaining causes of TLOC (n=2687) OR (95%CI) p-value
Anthropometric characteristics Anthropometric characteristics Anthropometric characteristics Anthropometric characteristics Anthropometric characteristics Anthropometric characteristics
Male gender 23.8% (750) 33.9% (158) 22.0% (592) 1.815 (1.47-2.24) <0.001
Children (<18 years-old) 15.6% (493) 24.0% (112) 14.4% (388) 1.875 (1.48-2.38) <0.001
Body mass index (kg/m²) 22.0±3.2 22.5±3.4 22.0±3.2 1.045 (1.02-1.08) 0.002
Physical activity Physical activity Physical activity Physical activity Physical activity Physical activity
Sports practice 43.9% (1379) 46.9% (217) 43.4%(1162) 1.149 (0.94-1.40) 0.168
Duration (in hours per week) 3[2-6] 4[2-6] 3[2-5] 1.021 (0.98-1.06) 0.243
Competitive sports practice 37.3% (1013) 43.0% (179) 36.2% (834) 1.328 (1.07-1.64) 0.009
Duration (in years) 4[3-7] 4[3-7] 4[2-7] 1.008 (0.96-1.05) 0.731
Moderate to high static and dynamic components 44.2% (1393) 47.2% (220) 43.6%(1173) 1.154 (0.95-1.41) 0.154
Syncopal event risk features Syncopal event risk features Syncopal event risk features Syncopal event risk features Syncopal event risk features Syncopal event risk features
Major high-risk features (7) - at least 1: 22.7% (717) 34.8% (162) 20.7% (555) 2.047 (1.66-2.53) <0.001
During exertion 8.8% (278) 24.7% (115) 6.1% (163) 5.073 (3.90-6.60) <0.001
Palpitations preceding syncope 16.6% (521) 17.4% (81) 16.4% (440) 1.074 (0.83-1.39) 0.589
Minor high-risk features (7) - at least 1: 16.6% (523) 28.5% (133) 14.5% (390) 2.352 (1.87-2.95) <0.001
No warning symptoms 15.3% (481) 26.6% (124) 13.3 (357) 2.366 (1.87-2.99) <0.001
Sudden death in relatives <40 years-old 1.5% (47) 2.2% (10) 1.4% (37) 1.588 (0.78-3.22) 0.199
Immediately after exertion 6.5% (206) 12.9% (60) 5.4% (146) 2.572 (1.87-3.54) <0.001
Intense malaise preceding syncope 31.1% (981) 19.4% (77) 32.8% (904) 0.528 (0.42-0.67) <0.001
Fever-related syncope 1.1% (35) 3.9% (18) 0.6% (17) 6.310 (3.23-12.34) <0.001
Recurrence of syncope (nº of events) 1.4±0.5 1.3±0.5 1.5±0.5 0.496 (0.39-0.63) <0.001
Syncope with resulting injury 9.8% (298) 10.4% (45) 9.8% (253) 1.073 (0.77-1.50) 0.679
Past personal and familiar medical history Past personal and familiar medical history Past personal and familiar medical history Past personal and familiar medical history Past personal and familiar medical history Past personal and familiar medical history
Palpitations with syncope or presyncope 5.9% (187) 7.7% (36) 5.6% (151) 1.406 (0.96-2.05) 0.077
Palpitations requiring medical assessment 4.12% (130) 5.8% (27) 3.8% (103) 1.543 (1.00-2.38) 0.051
Previous consultation with a Cardiologist 36.8% (1148) 41.3% (190) 36.0% (958) 1.250 (1.02-1.53) 0.020
Known cardiac disease* 0.5% (15) 0.2% (1) 0.5% (14) 0.410 (0.05-3.13) 0.390
Know cardiac disease in relatives* 3.0% (96) 1.3% (6) 3.4% (90) 0.376 (0.16-0.86) 0.021