Statistical Analysis
Continous variables are presented as mean and standard deviation or median and interquartile range where appropiate. Categorical variables are presented as absolute frequencies. Comparison of normally distributed continous variables was performed using Student t test. Two tailed paired Student’s t-tests were performed for continuous paired variables and Wilcoxon signed rank tests were used where appropriate. Tests were 2 sided, and a value of P<0.05 was considered statistically significant. All analyses were performed by using SPSS (IBM SPSS Statistics, Version 22.0, Armonk, New York, USA).