FIGURE 2 TA significantly inhibits the proliferation and growth
of pancreatic cancer cells. (a) Chemical structures of Trienomycins A,
B, C, D, E, F, G, J, K, and L. (b) Effect of trienomycins on the
proliferation of pancreatic cancer cells. Cells were treated with
different concentrations of trienomycins (0-10 μM) for 48 h. Cell
viability was measured with MTS assay. Data are shown as means ± SD (n =
5). (c) Effect of TA on the proliferation of pancreatic cancer cells.
Cells were treated with different concentrations of TA (0-10 μM) for 48
h or 72 h. Cell viability was measured with MTS assay. Data are shown as
means ± SD (n = 5). (d) Up: Effect of TA on the colony formation of
PANC-1 cells. Cells were seeded into six-well plates and treated with
different concentrations of TA (0-0.1 μM) for 7 days. Colonies were
stained with crystal violet and photographed by using a digital camera.
Down: Analysis of the results in (d). Colonies were counted by using
ImageJ software. Data are shown as means ± SD (n = 5). *P< 0.05.