Body Mass Index
The distribution of median BMI z-score is presented in Figure 1. We did
not observe any significant difference in BMI z-score over the first six
months of treatment (Fig. 1A) or significant changes in weight
classification across the study period (Supplementary Table #S2). To
evaluate differences in BMI by clinical and demographic variables
associated with increased BMI, Wilcoxon rank sum test was performed and
evaluated BMI by risk group, sex, and ethnicity at each timepoint (Fig.
1B-D). BMI z-scores were not significantly different between low risk,
intermediate risk, and high risk groups at study entry, end of
induction, or end of 6-months (Fig. 1B, P = 0.89, P =
0.48, and P = 0.19, respectively). BMI z-scores were also not
significantly different between females and males at each timepoint
(Fig. 1C, P = 0.69, P = 0.24, and P = 0.94,
respectively) or Hispanics and Non-Hispanics at each timepoint (Fig. 1D,P = 0.71, P = 0.88, and P = 0.13, respectively).
We performed median regression analysis to evaluate the relationship
between changes in dietary variables and BMI z-score (Supplementary
Table #S3). We did not find any additional significant relationships
between dietary intake of specific nutrients or food groups and BMI
z-score after adjustment for age at study entry, sex, ethnicity, and
baseline BMI z-score.