Specific ligand delivery

Some receptors have a specific or excessive expression on cancer cells. Binding molecules to nanoparticles that recognize cancerous cells via these receptors can improve the effectiveness of treatment. In addition, active targeting of delivery systems can be enhanced by tumor receptor-mediated targeting. Specific ligands for siRNA delivery to the different types of cancer cells include hyaluronic acid (HA), transferrin, antibody, single-chain variable fragment (scFv), EphrinA I, anisamide (AN), follicle-stimulating hormone (FSH), folic acid (FA), Epidermal growth factor receptor (EGFR), gastrin, octaarginine, and arginyl-glycyl-aspartic acid (RGD) (Aghamiri, Jafarpour, Malekshahi, Mahmoudi Gomari, & Negahdari, 2019). Of these, only antibody, gastrin, and RGD have been considered for siRNA delivery in pancreatic cancer among them, which have been completely review in this part.