RGD
RGD peptides are common ligands used for the delivery of siRNA into
cervical cancer cells due to the fact that they are directly related to
cancer angiogenesis and metabolism of quick-proliferating pancreatic
tumor cells. The RGD peptide can robustly and selectively interact with
overexpressed receptors of αvβ5 and αvβ3 integrins on pancreatic cancer
cells (Y. Sun et al., 2017). Kim et al . (H. A. Kim, Nam, & Kim,
2014) designed PA-PEG1k-RGD to deliver VEGF siRNA in PANC-1 cells. The
PA-PEG1k-RGD/VEGF siRNA complexes showed higher cellular uptake and gene
silencing than non-targeted ones.