Methods and Results
Fifty-one consecutive patients undergoing cryoballoon PVI were enrolled.
All patients underwent sedation using propofol throughout the procedure.
Sedation status was monitored by the bispectral index. After the
transseptal puncture and inserting the long sheath into the LA, the LAP
was measured via the sheath. Then, the ASV treatment was started, and
the LAP was re-measured. The LAP before and after the ASV support was
investigated.
Before the ASV, the LAP during inspiratory phase was significantly
smaller than that during expiratory phase (4.9±5.4 mmHg vs. 14.0±5.2
mmHg, p<0.01). The lowest LAP was -2.2±5.1 mmHg and was under
0 mmHg in 37 (73%) patients. After the ASV, the LAP during inspiratory
phase significantly increased to 8.9±4.1 mmHg (p<0.01), and
lowest LAP to 4.7±5.9 mmHg (p<0.01). The negative lowest LAP
value became positive in 30/37 (81%) patients. There were no
statistical differences regarding obstructive sleep apnea (OSA),
obesity, gender, or other comorbidities between patients with and
without a negative lowest LAP after the ASV support.