Viral clearance in end-to-end continuous process for mAb purification: Total flow-through integrated polishing on two columns connected to virus filtration
Hironobu Shirataki1, Yoshihiro Matsumoto2, Fuminori Konoike3, Shuichi Yamamoto4
1Scientific Affairs Group, Bioprocess Division, Asahi Kasei Medical Co., Ltd., 1-1-2, Yurakucho, Chiyoda-ku, Tokyo 100-0006, Japan
2Yokohama R&D Center, JNC Corporation, 5-1, Ookawa, Kanazawa-ku, Yokohama-shi, Kanagawa, 236-8605, Japan
3Bio-Pharma Research Laboratories, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago-shi, Hyogo, 676-8688, Japan
4 Yamaguchi University Biomedical Engineering Center (YUBEC), Yamaguchi University, 2-16-1 Tokiwadai, Ube, Yamaguchi 755-8611, Japan
Corresponding author: Hironobu Shirataki, Scientific Affairs Group, Bioprocess division, Asahi Kasei Medical Co., Ltd., 1-1-2, Yurakucho, Chiyoda-ku, Tokyo 100-0006, Japan.
email: shirataki.hb@om.asahi-kasei.co.jp
Co-author email addresses
Yoshihiro Matsumoto: ymatsumoto@jnc-corp.co.jp Fuminori Konoike: Fuminori.Konoike@kaneka.co.jp
Shuichi Yamamoto: shuichi@yamaguchi-u.ac.jp
Short running title: Viral clearance in continuous mAb process
This research was supported by grant number JP18ae0101056, JP18ae0101057 and JP18ae0101058 from the Japan Agency for Medical Research and Development (AMED)
Conflict of interest disclosure