3.2. Virus removability of total flow-through integrated polishing process
In the end-to-end continuous process for mAb purification, virus removal is expected for the Protein A capture, low pH virus inactivation, two column chromatography and virus filter steps, with the most robust virus removability at the virus filtration step. Here, viral clearance testes were carried out for specific segments of the total flow-through integrated polishing process.