†mAb solution (11 mg/mL) with no aggregate spike
‡Aggregate-spiked Ab solution (11 mg/mL); mAb (15
mg/mL) spiked at 1.0% with mAb aggregate (11.4% dimer and 33.3%
trimer or larger species) prepared for application to column
chromatography and nylon prefilter and adjusted to 11 mg/mL for analysis
and virus filtration
Table 2 Dimer and trimer or larger species content of
aggregate-spiked plasma IgG solutions used in the virus filtration
process.