Figure 2: Humoral factors influencing the allergic response
The anti-allergenic environment is characterized by a high IgG/IgE ratio
and allergen-specific IgG4-mediated inhibition. The pro-allergenic
environment includes high-affinity IgE driven by Tfh13 cells, high
epitope diversity and proximity, and increased glycosylation content in
the constant region of IgE. Low-affinity IgE is not a determining factor
for a pro nor anti-allergenic environment.