Risk Factors for All-Cause Mortality
On last follow-up, 47.1% (n=23,251) of the patient cohort was deceased.
African American race (HR 1.30, 95% CI 1.25-1.45, p<0.001),
stage IIIb and IV CKD (HR 1.14, 95% CI 1.07-1.20 and HR 1.19, 95% CI
1.08-1.30, both p<0.001), diabetes (HR 1.32, 95% CI
1.27-1.37, p<0.001), tobacco use (HR 1.23, 95% CI 1.16-1.31,
p<0.001), post-transplant stroke (HR 1.18, 1.05-1.33,
p=0.005), and post-transplant dialysis (HR 1.29, 95% CI 1.20-1.38,
p<0.001) were all associated with an increased risk of death
(Table 4 ). The development of a post-transplant DNM conferred a
43% increased risk of death (95% CI 1.38-1.47, p<0.001).Figure 3 depicts the Kaplan-Meier survival estimates of
patients with versus without DNM.