Hazard Ratio, All-Cause Mortality (95% Confidence Interval)
p value
Hazard Ratio, Cancer-Specific Mortality (95% Confidence Interval)
p value
Development of DNM 1.43 (1.38-1.47) <0.001
Age 1.01 (1.01-1.0) <0.001 1.04 (1.04-1.05) <0.001
Male gender 0.99 (0.95-1.02) 0.4 1.06 (0.96-1.17) 0.3
Race Caucasian African American Hispanic Asian Other Unknown Ref 1.30 (1.25-1.35) 0.96 (0.90-1.02) 0.88 (0.78-0.99) 1.08 (0.93-1.25) 1.07 (0.64-1.78) <0.001 0.2 0.04 0.3 0.8 Ref 0.83 (0.72-0.96) 0.79 (0.64-0.98) 0.56 (0.34-0.90) 0.95 (0.60-1.52) 2.40 (0.89-6.48) 0.01 0.03 0.02 0.8 0.08
Diagnosis at Listing Dilated Myopathy Restrictive Hypertrophic Prior graft failure CAD Valvular Disease Congenital Other Ref 1.07 (0.95-1.21) 0.72 (0.62-0.84) 1.29 (1.06-1.56) 1.17 (1.13-1.21) 0.87 (0.80-0.95) 0.98 (0.87-1.10) 0.96 (0.84-1.10) 0.3 <0.001 0.01 <0.001 0.001 0.7 0.6 Ref 1.16 (0.81-1.66) 0.68 (0.42-1.12) 0.76 (0.43-1.35) 1.08 (0.98-1.18) 0.85 (0.68-1.06) 1.45 (0.99-2.10) 1.11 (0.80-1.55) 0.4 0.1 0.4 0.1 0.1 0.05 0.5
Year Transplanted 1987 – 2004 2005 – 2018 Ref 1.08 (0.96-1.20)
0.2
Ref 1.09 (0.98-1.22)
0.1
Comorbidities BMI Higher GFR CKD stage II (Ref stage I) Stage IIIa Stage IIIb Stage IV Stage V Diabetes History smoking Cerebrovascular Disease 1.01 (1.01-1.01) 0.99 (0.99-0.99) 0.95 (0.91-0.99) 1.04 (0.99-1.10) 1.14 (1.07-1.20) 1.19 (1.08-1.30) 1.13 (0.92-1.39) 1.32 (1.27-1.37) 1.33 (1.20-1.48) 1.09 (1.01-1.19) <0.001 <0.001 0.03 0.1 <0.001 <0.001 0.2 <0.001 <0.001 0.03 1.00 (0.99-1.01) 1.08 (0.97-1.21) 1.37 (1.16-1.63) 1.34 (1.08-1.66) 1.0 0.2 <0.001 0.007
Infectious Disease Serology HBV Core Ab (+) HCV (+) CMV (+) EBV (+) 1.06 (0.98-1.15) 1.30 (1.17-1.43) 0.97 (0.76-1.22) 0.92 (0.86-0.99) 0.1 <0.001 0.8 0.02 1.09 (0.87-1.37) 1.23 (0.92-1.66) 0.83 (0.35-1.96) 1.07 (0.88-1.31) 0.4 0.2 0.7 0.5
Post-Op Complications Stroke Dialysis 1.18 (1.05-1.33) 1.29 (1.20-1.38) 0.005 <0.001 1.10 (0.78-1.55) 0.91 (0.73-1.13) 0.6 0.4
Induction Therapy Basiliximab ATG 1.03 (0.99-1.08) 1.14 (1.07-1.22) 1.02 (0.97-1.06) 0.1 <0.001 0.5 1.10 (0.84-1.05) 0.91 (1.00-1.43) 1.15 (1.03-1.30) 0.3 0.06 0.01
Maintenance Therapy Calcineurin inhibitor mTOR inhibitor MMF Steroid 1.03 (0.97-1.10) 0.92 (0.83-1.01) 0.93 (0.89-0.97) 0.98 (0.92-1.04) 0.3 0.8 <0.001 0.6 1.30 (1.09-1.56) 0.82 (0.60-1.13) 0.94 (0.84-1.05) 0.83 (0.70-0.98) 0.004 0.2 0.2 0.03