Development of DNM |
1.43 (1.38-1.47) |
<0.001 |
|
|
Age |
1.01 (1.01-1.0) |
<0.001 |
1.04 (1.04-1.05) |
<0.001 |
Male gender |
0.99 (0.95-1.02) |
0.4 |
1.06 (0.96-1.17) |
0.3 |
Race
Caucasian
African American
Hispanic
Asian
Other
Unknown
|
Ref
1.30 (1.25-1.35)
0.96 (0.90-1.02)
0.88 (0.78-0.99)
1.08 (0.93-1.25)
1.07 (0.64-1.78)
|
<0.001
0.2
0.04
0.3
0.8
|
Ref
0.83 (0.72-0.96)
0.79 (0.64-0.98)
0.56 (0.34-0.90)
0.95 (0.60-1.52)
2.40 (0.89-6.48)
|
0.01
0.03
0.02
0.8
0.08
|
Diagnosis at Listing
Dilated Myopathy
Restrictive
Hypertrophic
Prior graft failure
CAD
Valvular Disease
Congenital
Other
|
Ref
1.07 (0.95-1.21)
0.72 (0.62-0.84)
1.29 (1.06-1.56)
1.17 (1.13-1.21)
0.87 (0.80-0.95)
0.98 (0.87-1.10)
0.96 (0.84-1.10)
|
0.3
<0.001
0.01
<0.001
0.001
0.7
0.6
|
Ref
1.16 (0.81-1.66)
0.68 (0.42-1.12)
0.76 (0.43-1.35)
1.08 (0.98-1.18)
0.85 (0.68-1.06)
1.45 (0.99-2.10)
1.11 (0.80-1.55)
|
0.4
0.1
0.4
0.1
0.1
0.05
0.5
|
Year Transplanted
1987 – 2004
2005 – 2018
|
Ref
1.08 (0.96-1.20)
|
0.2
|
Ref
1.09 (0.98-1.22)
|
0.1
|
Comorbidities
BMI
Higher GFR
CKD stage II
(Ref stage I)
Stage IIIa
Stage IIIb
Stage IV
Stage V
Diabetes
History smoking
Cerebrovascular
Disease
|
1.01 (1.01-1.01)
0.99 (0.99-0.99)
0.95 (0.91-0.99)
1.04 (0.99-1.10)
1.14 (1.07-1.20)
1.19 (1.08-1.30)
1.13 (0.92-1.39)
1.32 (1.27-1.37)
1.33 (1.20-1.48)
1.09 (1.01-1.19)
|
<0.001
<0.001
0.03
0.1
<0.001
<0.001
0.2
<0.001
<0.001
0.03
|
1.00 (0.99-1.01)
1.08 (0.97-1.21)
1.37 (1.16-1.63)
1.34 (1.08-1.66)
|
1.0
0.2
<0.001
0.007
|
Infectious Disease Serology
HBV Core Ab (+)
HCV (+)
CMV (+)
EBV (+)
|
1.06 (0.98-1.15)
1.30 (1.17-1.43)
0.97 (0.76-1.22)
0.92 (0.86-0.99)
|
0.1
<0.001
0.8
0.02
|
1.09 (0.87-1.37)
1.23 (0.92-1.66)
0.83 (0.35-1.96)
1.07 (0.88-1.31)
|
0.4
0.2
0.7
0.5
|
Post-Op Complications
Stroke
Dialysis
|
1.18 (1.05-1.33)
1.29 (1.20-1.38)
|
0.005
<0.001
|
1.10 (0.78-1.55)
0.91 (0.73-1.13)
|
0.6
0.4
|
Induction Therapy
Basiliximab
ATG
|
1.03 (0.99-1.08)
1.14 (1.07-1.22)
1.02 (0.97-1.06)
|
0.1
<0.001
0.5
|
1.10 (0.84-1.05)
0.91 (1.00-1.43)
1.15 (1.03-1.30)
|
0.3
0.06
0.01
|
Maintenance Therapy
Calcineurin inhibitor
mTOR inhibitor
MMF
Steroid
|
1.03 (0.97-1.10)
0.92 (0.83-1.01)
0.93 (0.89-0.97)
0.98 (0.92-1.04)
|
0.3
0.8
<0.001
0.6
|
1.30 (1.09-1.56)
0.82 (0.60-1.13)
0.94 (0.84-1.05)
0.83 (0.70-0.98)
|
0.004
0.2
0.2
0.03
|