Mean age, years (SD) |
53.8 (10.1) |
51.4 (12.3) |
<0.001 |
1.03 (1.03-1.03) |
<0.001 |
Male Gender |
7,443 (82.6%) |
30,433 (75.4%) |
<0.001 |
1.24
(1.17-1.31) |
<0.001 |
Race
Caucasian
African American
Hispanic
Asian
Other
Unknown
|
7,600 (84.4%)
914 (10.1%)
336 (3.7%)
90 (1.0%)
56 (0.6%)
10 (0.1%)
|
29,624 (73.4%)
6,578 (16.3%)
2,740 (6.8%)
988 (2.4%)
412 (1.0%)
139 (0.03%)
|
<0.001
|
Ref
1.05 (0.97-1.13)
0.78 (0.70-0.87)
0.68 (0.55-0.84)
0.90 (0.69-1.17)
1.16 (0.55-2.44)
|
0.2
<0.001
<0.001
0.4
0.7
|
Diagnosis at Listing
Dilated Myopathy
Restrictive
Hypertrophic
Prior graft failure
CAD
Valvular Disease
Congenital
Other
|
5,552 (61.6%)
96 (1.1%)
66 (0.7%)
204 (2.3%)
2,591 (28.8%)
255 (2.8%)
91 (1.0%)
117 (1.3%)
|
30,363 (75.2%)
776 (1.9%)
745 (1.8%)
873 (2.2%)
5,020 (12.4%)
953 (2.4%)
939 (2.3%)
624 (1.5%)
|
<0.001
|
Ref
0.99 (0.80-1.21)
0.75 (0.59-0.96)
1.66 (1.25-2.21)
1.03 (0.97-1.08)
0.88 (0.77-0.99)
0.89 (0.72-1.10)
1.19 (0.98-1.44)
|
0.9
0.02
0.001
0.4
0.04
0.3
0.08
|
Year Transplanted
1987 –2004
2005 – 2018
|
|
|
|
Ref
1.05 (0.87-1.27)
|
0.6
|
Comorbidities
Mean BMI, kg/m2 (SD)
Mean GFR,
mL/min/1.73m2 (SD)
Diabetes
History smoking
Cerebrovascular
Disease
|
25.8 (4.3)
66.1 (23.9)
1,057/4,930 (21.4%)
1,050/1,783 (58.9%)
195/4,913 (4.0%)
|
26.5 (4.8)
70.6 (26.0)
7,936/33,988 (23.3%)
9,910/21,403 (46.3%)
1,581/33,772 (4.7%)
|
<0.001
<0.001
<0.001
<0.001
<0.001
|
1.00 (1.00-1.01)
0.99 (0.99-0.99)
0.99 (0.93-1.07)
1.39 (1.27-1.53)
0.98 (0.85-1.13)
|
0.3
<0.001
0.9
<0.001
0.8
|
Infectious Disease Serology
HBV Core Ab (+)
HCV (+)
CMV (+)
EBV (+)
|
244/5,630 (4.3%)
118/6,112 (1.9%)
1,957/3,136 (62.4%)
2,186/2,845 (76.8%)
|
1,378/31,422 (4.4%)
720/34,377 (2.1%)
16,251/26,732 (60.8%)
19,939/22,955 (86.9%)
|
<0.001
<0.001
<0.001
<0.001
|
1.19 (1.04-1.35)
1.01 (0.84-1.22)
0.56 (0.39-0.82)
0.91 (0.81-1.02)
|
0.01
0.9
0.003
0.1
|
Induction Therapy
Basiliximab
ATG
|
6,104 (67.8%)
451 (5.0%)
909 (10.1%)
|
30,280 (75.0%)
5,662 (14.0%)
6,602 (16.4%)
|
<0.001
<0.001
<0.001
|
0.98 (0.92-1.05)
0.98 (0.88-1.09)
1.00 (0.93-1.08)
|
0.6
0.7
0.9
|
Maintenance Therapy
Calcineurin inhibitor
mTOR inhibitor
MMF
Steroid
|
6,918 (76.8%)
123 (1.4%)
3,249 (36.1%)
7,064 (78.4%)
|
36,771 (91.1%)
773 (1.9%)
27,156 (67.3%)
36,107 (89.5%)
|
<0.001
<0.001
<0.001
<0.001
|
0.91 (0.82-1.01)
0.85 (0.71-1.03)
0.89 (0.83-0.96)
1.03 (0.94-1.13)
|
0.07
0.09
0.001
0.5
|
Post-Op Complications
Stroke
Dialysis
|
82/5,050 (1.6%)
261/5,055 (5.2%)
|
594/4,139 (1.7%)
1,988/34,158 (5.8%)
|
<0.001
<0.001
|
1.00 (0.80-1.24)
1.17 (1.03-1.33)
|
1.0
0.01
|