Cardiac tumors are a rare disease in clinical practice. Two patients with primary cardiac malignancies were admitted to our hospital from May 2020 to July 2020. The first patient‘s heart tumor is non-Hodgkin’s lymphoma, which originated in the right atrium and invaded part of the right atrium and superior vena cava. The tumor was completely removed and the right atrium and superior vena cava were reconstructed after surgery. The prognosis of the patients after chemotherapy is fair. The second patient’s tumor also originated in the right atrium, which was an epithelioid hemangioendothelioma, it was highly malignant and had a wide range of tumor invasion. The right atrium, left atrium, right ventricle, aortic root, and superior and inferior vena cava were all involved and could not be completely surgically removed, so the patient’s prognosis is poor.
