Association between antibiotic exposure within 6 months of age
and AD
In multivariable regression analyses, antibiotic exposure within 6
months of age increased the risk of AD at each visit after adjusting for
sex, maternal education, family history of allergic disease,
breastfeeding, and mode of delivery (Fig. 1; at the age of 6 months:
aOR=1.30, 95% CI 0.99–1.71, p=0.06; at 1 year: aOR=1.28, 95% CI
1.00–1.65, p=0.05 at 2 years: aOR=1.38, 95% CI 1.08–1.77, p=0.01; at
3 years: aOR=1.40, 95% CI 1.09–1.81, p=0.01). Furthermore, the more
the antibiotics were prescribed, the higher was the dose-dependent risk
of AD at 6 months to 3 years (Fig. E1).