Objective Patent ductus arteriosus (PDA) is an important cause of morbidity and mortality, especially in very‐low‐birth‐weight infants. The aim of the study is to report our single-center short-term results of preterm patients who underwent patent ductus arteriosus ligation through left anterior mini-thoracotomy . Methods Data of 27 preterm infants operated by the same surgeon who underwent PDA closure with left anterior minithoracotomy technique between November 2020 and January 2022 at a single instution were reviewed. The patients were divided into two groups according to their weight at the time of surgery. Data on early postoperative outcomes and survival rates after discharge were collected. Results Twenty-seven patients with a mean (±SD) gestational age of 25.8 (±2.0) weeks and a mean birth weight of 1027 (±423) g were operated using left anterior mini-thoracotomy technique. The lowest body weight was 480 g. Complications such as bleeding, abnormal healing of incision or pneumothorax were not seen. There were 8 mortalities after the operation (29,6 %). There was no internal thoracic artery injury or no need for conversion to thoracotomy or sternotomy. there were 6 (22%) deaths in the postoperative first 30 days and 4 (14,8%) deaths between the postoperative first month and first year. The cause of the deaths were sepsis, NEC, hydrops fetalis, hepatoblastoma and intracranial bleeding. Left diaphragmatic elevation developed in 1 patient, and plication was performed. There was no statistically significant difference in the rates of morbidity, and complication between the groups. Conclusions PDA closure with the left anterior mini-thoracotomy method is advantageous in terms of reducing damage to the already congested lung, shortening the hypothermia time of the baby by shortening the procedure time, and has good cosmetic results, especially in very low birth weight preterm babies.