Introduction
Five-fluorouracil (5-FU) remains a first line treatment in oncology with a potential of cardiovascular toxicity.1 Although coronary vasospasm has been well described, acute heart failure has been scarcely reported.2 We identified two cases of acute severe cardiac toxicity treated with a combination of 5FU (different production batch) and platins at three months interval at two different institutions referred to our cardio-oncology services.