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Probable long-term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama
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  • Fermin Acosta,
  • Anders Norman,
  • Dilcia Sambrano,
  • Victoria Batista,
  • Igor Mokrousov,
  • Egor Shitikov,
  • Julio Jurado,
  • Maritza Mayrena,
  • Odemaris Luque,
  • Maybis Garay,
  • Laura Solis,
  • Patricia Muñoz,
  • Dorte Bek Folkvardsen,
  • Troels Lillebaek,
  • laura Pérez-Lago,
  • Amador Goodridge,
  • Darío García de Viedma
Fermin Acosta
Hospital General Universitario Gregorio Marañón

Corresponding Author:fermin2819@gmail.com

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Anders Norman
International Reference Laboratory of Mycobacteriology
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Dilcia Sambrano
INDICASAT
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Victoria Batista
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Igor Mokrousov
St. Petersburg Pasteur Institute
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Egor Shitikov
Federal Research and Clinical Center of Physical-Chemical Medicine
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Julio Jurado
Caja de Seguro Social
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Maritza Mayrena
Caja de Seguro Social
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Odemaris Luque
Programa de Control de Tuberculosis, Ministerio de Salud
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Maybis Garay
INDICASAT
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Laura Solis
Programa de Control de Tuberculosis, Ministerio de Salud
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Patricia Muñoz
Hospital General Universitario Gregorio Marañón
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Dorte Bek Folkvardsen
International Reference Laboratory of Mycobacteriology
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Troels Lillebaek
International Reference Laboratory of Mycobacteriology
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laura Pérez-Lago
Hospital General Universitario Gregorio Marañón
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Amador Goodridge
INDICASAT
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Darío García de Viedma
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Abstract

Beijing genotype Mycobacterium tuberculosis strains associate with increased virulence, resistance, and/or higher transmission rates. This study describes a specific Beijing strain predominantly identified in the Panamanian province of Colon with one of the highest incidence of tuberculosis in the country. Retrospective Mycobacterial Interspersed Repetitive-Unit/Variable-Number of Tandem Repeats analysis of 42 isolates collected between January-August 2018, allowed to identify a cluster (Beijing A) with 17 (40.5%) Beijing isolates. Subsequent prospective strain-specific PCR based surveillance from September 2019 to March 2020, confirmed the predominance of the Beijing A strain (44.1%) in this province. Whole genome sequencing revealed higher-than-expected diversity within the cluster, suggesting long-term prevalence of this strain and low number of cases caused by recent transmission. The Beijing A strain belongs to the Asian African 3 (Bmyc13, L2.2.5) branch of the modern Beijing sublineage, with their closest isolates corresponding to cases from Vietnam, probably introduced in Panama between 2000 and 2012.
24 Aug 2020Submitted to Transboundary and Emerging Diseases
25 Aug 2020Submission Checks Completed
25 Aug 2020Assigned to Editor
26 Aug 2020Reviewer(s) Assigned
18 Sep 2020Review(s) Completed, Editorial Evaluation Pending
19 Sep 2020Editorial Decision: Revise Minor
24 Sep 20201st Revision Received
25 Sep 2020Submission Checks Completed
25 Sep 2020Assigned to Editor
25 Sep 2020Reviewer(s) Assigned
05 Oct 2020Review(s) Completed, Editorial Evaluation Pending
06 Oct 2020Editorial Decision: Accept
13 Oct 2020Published in Transboundary and Emerging Diseases. 10.1111/tbed.13875