Introduction: Patient adherence is a cornerstone in successful management of psychiatric disorders and is affected by patient perspectives and barriers, differing from rural to urban areas. In this perspective, pharmacists have a vital role in identifying patients in need of help and in dealing with barriers to adherence. This paper investigates perspectives of patients diagnosed with psychiatric disorders, living in rural areas in Jerash, Jordan, regarding their awareness about their psychiatric conditions, including religious and cultural factors, adherence to their treatment and related barriers, with special focus on pharmacist’s role. Methods: This cross-sectional survey study was conducted in Jordan from August to November 2019. A validated questionnaire was administered by two pharmacists, asking patients as they were waiting in the psychiatric clinic (following the specialists’ approval). Data were analyzed using the Statistical Package for the Social Science (SPSS). Results: Most patients (n= 120, age 39.4±9.5, 66.7% males) reported that they always/usually adhere to their medications (71.0%), and 47.5% of them reported complete control of their symptoms after treatment. Most patients (69.2%) reported that they perceive their psychological illness in terms of religious faith as being counted for their favor in the Hereafter, and 52.5% of them always/usually looked at themselves positively and unaffected by the existence of their illness; with both factors correlating significantly with better treatment adherence (p < 0.045 and p < 0.001; respectively). Barriers affecting adherence included mainly suffering from adverse effects (31.9%) and being unconvinced that they needed a medication (23.3%). Only 14.2% of patients reported that they refer to the pharmacist to get information about their medications. Conclusion: Most psychiatric patients reported suboptimal control of their symptoms. Nonadherence is one reason, with barriers identified. Positive religious and cultural perspectives are associated with better adherence, and most patients do not refer to pharmacists for medication informatio