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Advances and highlights in biomarkers of allergic diseases
  • +25
  • Ismail Ogulur,
  • Yağız Pat,
  • Ozge Ardicli,
  • Elena Barletta,
  • Lacin Cevhertas,
  • Ruben Fernandez-Santamaria,
  • Mengting Huang,
  • Manal Bel Imam,
  • Jana Koch,
  • Siyuan Ma,
  • debbie maurer,
  • yasutaka mitamura,
  • Yaqi Peng,
  • Urszula Radzikowska,
  • Arturo Rinaldi,
  • Juan Rodriguez-Coira,
  • Pattraporn Satitsuksanoa,
  • Stephan Schneider,
  • Alexandra Wallimann,
  • Damir Zhakparov,
  • Reihane Ziadlou,
  • Marie-Charlotte Brüeggen,
  • Willem van de Veen,
  • Milena Sokolowska,
  • Katja Baerenfaller,
  • Luo Zhang,
  • Mubeccel Akdis,
  • Cezmi Akdis
Ismail Ogulur
University of Zurich

Corresponding Author:ismail.ogulur@gmail.com

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Yağız Pat
University of Zurich
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Ozge Ardicli
University of Zurich
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Elena Barletta
University of Zurich
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Lacin Cevhertas
University of Zurich
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Ruben Fernandez-Santamaria
University of Zurich
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Mengting Huang
University of Zurich
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Manal Bel Imam
University of Zurich
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Jana Koch
University of Zurich Swiss Institute of Allergy & Asthma Research
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Siyuan Ma
University of Zurich Swiss Institute of Allergy & Asthma Research
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debbie maurer
University of Zurich
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yasutaka mitamura
University of Zurich
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Yaqi Peng
University of Zurich
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Urszula Radzikowska
University of Zurich
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Arturo Rinaldi
University of Zurich
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Juan Rodriguez-Coira
University of Zurich
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Pattraporn Satitsuksanoa
University of Zurich
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Stephan Schneider
University of Zurich
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Alexandra Wallimann
University of Zurich Swiss Institute of Allergy & Asthma Research
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Damir Zhakparov
University of Zurich
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Reihane Ziadlou
Christine Kühne Center for Allergy Research and Education
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Marie-Charlotte Brüeggen
Christine Kühne Center for Allergy Research and Education
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Willem van de Veen
University of Zurich
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Milena Sokolowska
University of Zurich
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Katja Baerenfaller
University of Zurich
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Luo Zhang
Capital Medical University
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Mubeccel Akdis
University of Zurich
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Cezmi Akdis
University of Zurich
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Abstract

Allergic diseases include asthma, atopic-dermatitis, allergic-rhinitis, drug hypersensitivity and food-allergy. During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical-burden. A large fraction of allergic diseases is characterized by a type-2 immune response involving Th2 cells, type-2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies. The availability of powerful omics technologies, together with integrated data analysis and network-based approaches can help the identification of clinically useful biomarkers. These biomarkers need to be accurately quantified using robust and reproducible methods, such as reliable and point-of-care systems. Ideally, samples should be collected using quick, cost-efficient and non-invasive methods. In recent years, a plethora of research has been directed towards finding novel biomarkers of allergic diseases. Promising biomarkers of type-2 allergic diseases include sputum eosinophils, serum periostin and exhaled nitric-oxide. Several other biomarkers, such as pro-inflammatory mediators, miRNAs, eicosanoid molecules, epithelial barrier integrity, and microbiota changes are useful for diagnosis and monitoring of allergic diseases and can be quantified in serum, body-fluids and exhaled-air. Herein, we review recent studies on biomarkers for the diagnosis and treatment of asthma, chronic-urticaria, atopic-dermatitis, allergic-rhinitis, chronic-rhinosinusitis, food-allergies, anaphylaxis, drug hypersensitivity and allergen-immunotherapy. In addition, we discuss COVID-19 and allergic diseases within the perspective of biomarkers and recommendations on the management of allergic and asthmatic patients during the COVID-19 pandemic.
19 May 2021Submitted to Allergy
20 May 2021Submission Checks Completed
20 May 2021Assigned to Editor
20 May 2021Reviewer(s) Assigned
07 Jun 2021Review(s) Completed, Editorial Evaluation Pending
07 Jun 2021Editorial Decision: Revise Minor
Dec 2021Published in Allergy volume 76 issue 12 on pages 3659-3686. 10.1111/all.15089