The “Belt and Road Initiative” (BRI) was anticipated in 2013 to promote socio-economic development and cooperation across countries in Asia, Europe, Africa and worldwide. Rapid land-use changes and infrastructure developments driven by the BRI program are expected in the coming decades. These anthropogenic effects are likely to exaggerate the process of de-vegetation, deforestation, accelerating desertification, which is one of the major threats to the BRI region. This manuscript studied the desertification facts (i.e. spatiotemporal pattern, impacts and impacting factors) and investigated key aspects for desertification control (i.e. mitigation and evaluation methods) in the BRI countries via an extensive review of literature. We found that desertification has been prevalent in the BRI countries, predominantly in C Asia, but quantitative assessment of desertification is yet fully understood. This review illustrated that desertification was driven by climatic dryness and mis-land-use/management activities, but their relative importance has yet been (quantitatively) assessed along the BRI countries. Given the negative impacts of desertification, these BRI countries have ratified the UN Convention to Combat Desertification (UNCCD) to reduce negative impacts. The implementation of desertification mitigation programmes are currently still lacking. We argued that desertification is usually evaluated via four type of approaches, including quantitative approaches, indirect detection, direct observation and biophysical measurement (e.g. vegetation growth). Future research should be applied by considering the research scope and data availability. Overall, we conclude that BRI countries should carry out transboundary control on desertification. Otherwise, this issue is likely to extend further imminent developments under the foremost BRI program.