Background: Risk factors for hepatitis C complication including diabetes and hypertension have seen in a many previous studies. This made the need for prompted interest in prevention through the identifying individuals at risk for these risk factors and increased investment in screening by pharmacist. Objectives: The aim of this study is to screen for several risk factors include (age, sex, BMI, Hypertension, diabetes and obesity) in HCV positive (1959) Egyptian patients. Setting: Prospective cross sectional study from September 2018 to February 2019. A total of 1959 medical records were collected. By comparing the patient characteristics, variables related to metabolic risk and body composition measured. Regression models were built to adjust for possible confounding factors. Results: The positive HCV antibody prevalence rate was 41.0 % in men and 59.0 % in women. The variables included in regression analysis are age, BMI, uncontrolled HTN were statistically significant (P < 0.001) with DM in HCV positive cases. HCV Patients with high BMI with age ≥40 (years) associated significantly with diabetes and HTN (p<0.001). Hypertensive HCV Egyptian patients were significantly associated with sex, age >40 and DM (p< 0.001). Conclusion HCV infection and metabolic disorders spin in a closed cycle relationship. Reducing the complications of DM has a promising future of limiting the complications of HCV.