Primary diffuse leptomeningeal melanomatosis Leading to raised intracranial pressure in pediatric patientShiva Sareh1,Zohre Habibi2,Mohammad Vasei3,Moeindin Safavi4,Alieh Safari Sharari5 Neda Pak6, \RL Golazin shahbodagh khan7 , Mahmoudreza Ashrafi8 ,Morteza Heidari9 *

We reported an association between SARS-CoV-2 infection and Guillain-Barre´ syndrome (GBS). From 37 patients with GBS, Previous SARS-CoV-2 infection clues, including fever, cough, and diarrhea were recorded in 18 patients. Among them, SARS-CoV-2 IgG was detected in 7 patients, considered confirmed cases. SARS-CoV-2 PCR was positive in just 1 patient.

Here, an 8-year-old girl is reported with bilateral horizontal gaze palsy, ataxia and drowsiness. Brain MRI demonstrated dorsal midbrain, bilateral putamen nuclei and cerebellar dentate nucleus involvement. MRS revealed an elevated lactate peak which suggested a mitochondrial disease. Finally, the molecular genetic test reported NDUFS4 gene mutation