not-yet-known not-yet-known not-yet-known unknown Background: Allergic bronchopulmonary aspergillosis (ABPA), which is one of the respiratory complications of cystic fibrosis, is a hypersensitivity reaction in the lung against the antigens of the fungus Aspergillus fumigatus ( A.fumigatus). If left untreated, it may cause irreversible deteriorations in lung functions. The aim of this study is to determine the incidence of ABPA, according to years and to determine the risk factors leading to the development of ABPA by using the CF Registry System of Turkey data. Methods: The study was designed as a retrospective cohort study. Using the CF Registry System of Turkey data, the incidence of ABPA was determined and the data of 44 patients newly diagnosed with ABPA in 2022 and 132 patients with similar mutation weight and age range without ABPA diagnosis in that year were compared, and the risk factors affecting the development of ABPA were determined. Results: Low pulmonary function test values, having had at least one pulmonary exacerbation in that year and receiving intravenous antibiotic treatment, using inhaled antibiotics, having a high number of pulmonary exacerbations, having Pseudomonas aeroginosa (P.aeroginosa) colonization, having a low body mass index (BMI) and having cystic fibrosis related diabetes mellitus (CFRD) were found to be among the risk factors for the development of ABPA. Conclusions: Early recognition and treatment of ABPA is essential to prevent further damage to the lungs. Patients with frequent pulmonary exacerbations, low BMI and low pulmonary function test values, chronic colonization should definitely be considered for ABPA.

Background : We aimed to investigate food allergen sensitization as a prognostic factor of new onset wheezing episodes as well as of wheezing severity during follow up in young children with recurrent wheezing. Our secondary aim was to compare serum levels of Club Cell-16 (CC-16) and surfactant protein D (SP-D) among wheezing children with and without food allergen sensitization as potential pathogenetic indicators of the association between food allergen sensitivity and wheezing. Methods : This was a prospective cohort study among children with recurrent wheezing; specific-IgE to five common foods allergens was assessed at baseline and children were followed-up for one year for new onset wheezing episodes. Baseline wheezing severity score, CC-16 and SP-D levels were measured. Results : We enrolled 295 children among which 44 were food specific IgE (Fx5) (+). Poisson regression analysis with food allergen sensitivity, age and wheezing score at presentation revealed that Fx5 positivity changed yearly frequency of wheeze by a factor of 1.66 (p=0.05, 95%CI: (0.99-2.75)). Age changed the yearly frequency of wheeze by a factor of 0.95 (p=0.005, 95%CI: (0.92-0.99)). One-point change in wheezing score at presentation changed the wheezing frequency in the following year by a factor of 1.11 (p=0.005, 95%CI: (0.67-1.99)). Levels of CC-16 and SP-D were not significantly different between the two groups (p=0.679 and p=0.988). Conclusion : Food allergen sensitization defined as serum specific IgE positivity irrespective of food associated clinical allergy findings is associated with worse prognosis of wheezing in children.

Background: Change in airway resistance and inflammation are the two most commonly accused pathogenetic processes in the coexistence of asthma and obesity. The aim of this study was to compare airway resistance between normal weight and overweight/obese children using impulse oscillometry (IOS). Methods: We consecutively enrolled 3 to 10-year-old children with asthma who presented to our department between May and August 2018. Ones with a body mass index percentile at or above 85th percentile were grouped as overweight/obese. Sociodemographic characteristics such as age, sex and family history of allergy were recorded and Test for Respiratory and Asthma Control in Kids (TRACK) was filled in for all. Finally, impulse oscillometric (IOS) measurements were taken. Results: We enrolled 170 subjects; among which 114 (67.1%) were normal weight while 56 (33%) were overweight/obese. Sociodemographic characteristics were not significantly different between the two groups, but asthma control was significantly worse in the overweight/obese group (75.9±21.1 vs 85.9±17.8, p=0.001). Impulse oscillometric measurements of resistance and reactance were nor significantly different between the two groups. Conclusion: Asthma control in children who are overweight or obese are worse compared to the normal weight ones but, airway resistance and reactance measured by IOS at different frequencies are not significantly different between these two groups. This implies that airway resistance change may not the main pathogenetic mechanism underlying the uncontrolled asthma and obesity coexistence.

Background: Change in airway resistance and inflammation are the two most commonly accused pathogenetic processes in the coexistence of asthma and obesity. The aim of this study was to compare airway resistance between normal weight and overweight/obese children using impulse oscillometry (IOS). Methods: We consecutively enrolled 3 to 10-year-old children with asthma who presented to our department between May and August 2018. Ones with a body mass index percentile at or above 85th percentile were grouped as overweight/obese. Sociodemographic characteristics such as age, sex and family history of allergy were recorded and Test for Respiratory and Asthma Control in Kids (TRACK) was filled in for all. Finally, impulse oscillometric (IOS) measurements were taken. Results: We enrolled 170 subjects; among which 114 (67.1%) were normal weight while 56 (33%) were overweight/obese. Sociodemographic characteristics were not significantly different between the two groups, but asthma control was significantly worse in the overweight/obese group (75.9±21.1 vs 85.9±17.8, p=0.001). Impulse oscillometric measurements of resistance and reactance were nor significantly different between the two groups. Conclusion: Asthma control in children who are overweight or obese are worse compared to the normal weight ones but, airway resistance and reactance measured by IOS at different frequencies are not significantly different between these two groups. This implies that airway resistance change may not the main pathogenetic mechanism underlying the uncontrolled asthma and obesity coexistence.