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The presentation of nephrotic syndrome during immunosuppressive treatment for aplastic anemia with monosomy 7 in a 16-year-old boy: a case report
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  • Masato Yanagi,
  • Ryoji Kobayashi,
  • Satoru Matsushima,
  • Daiki Hori,
  • Hirozumi Sano,
  • Mayumi Yoshihara,
  • Kunihiko Kobayashi
Masato Yanagi
Sapporo Hokuyu Byoin

Corresponding Author:masatoyanagi0325@yahoo.co.jp

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Ryoji Kobayashi
Sapporo Hokuyu Byoin
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Satoru Matsushima
Sapporo Hokuyu Byoin
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Daiki Hori
Sapporo Hokuyu Byoin
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Hirozumi Sano
Sapporo Hokuyu Byoin
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Mayumi Yoshihara
Sapporo Hokuyu Byoin
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Kunihiko Kobayashi
Sapporo Hokuyu Byoin
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Abstract

Most cases of aplastic anemia (AA) complicated by nephrotic syndrome (NS) have been reported to be the effects of chronic graft-versus-host disease after hematopoietic stem cell transplantation (HSCT). We describe a 16-year-old boy with AA with monosomy 7 who developed NS during immunosuppressive treatment for AA alone without HSCT. Recently, there appeared a report of MIRAGE syndrome caused by gain-of-function mutation of SAMD9 gene on chromosome 7 who developed NS. No such mutation was detected in our patient and thus the genetic factors leading to the complication of two diseases remain unknown at this time.