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Hepatic cirrhosis in two patients with neuroblastoma receiving hematopoietic stem cell transplantation
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  • Daiki Hori,
  • Ryoji Kobayashi,
  • Daisuke Suzuki,
  • Hirozumi Sano,
  • Masato Yanagi,
  • Satoru Matsushima,
  • Kunihiko Kobayashi
Daiki Hori
Sapporo Hokuyu hospital

Corresponding Author:pippen33_dh@yahoo.co.jp

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Ryoji Kobayashi
Sapporo Hokuyu hospital
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Daisuke Suzuki
Sapporo Hokuyu Hospital
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Hirozumi Sano
Sapporo Hokuyu Hospital
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Masato Yanagi
Sapporo Hokuyu Hospital
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Satoru Matsushima
Sapporo Hokuyu Hospital
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Kunihiko Kobayashi
Sapporo Hokuyu Hospital
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Abstract

Hepatic cirrhosis is a very rare complication of hematopoietic stem cell transplantation (SCT) and of neuroblastoma. We encountered two patients developing cirrhosis after SCT against neuroblastoma. A 6-year-old boy who had received allogeneic bone marrow transplantation developed cirrhosis 10 years after the SCT with the massive upper gastrointestinal hemorrhage. A 27-year-old man receiving allogeneic cord blood transplantation against recurrence of neuroblastoma, died of liver failure due to histological cirrhosis 1 year after the SCT. We could not detect the definite etiologic candidates of cirrhosis; however, careful monitoring appears warranted to avoid overlooking the onset and progression of cirrhosis after SCT.