Poor Metabolizer
(e.g.,*4|*4, *3|*6)
|
CYP2D6 PMs may experience reduced analgesic effects from certain opioids
(e.g., codeine, tramadol, oxycodone, hydrocodone) due to reduced
production of the active metabolites.
|
Select alternate or monitor closely for symptoms of insufficient pain
relief.
|
Intermediate Metabolizer
(e.g.,
*9|*40, *2|*4)
|
CYP2D6 IMs may experience reduced
analgesic effects from certain opioids (e.g., codeine, tramadol,
oxycodone, hydrocodone) due to reduced production of the active
metabolites. |
Select alternate drug or monitor closely for symptoms of
insufficient pain relief. |
Normal (Extensive) Metabolizer
(e.g.,
*2/*2, *1/*41)
|
CYP2D6 NMs will likely experience the desired effects
of certain opioids (e.g., codeine, tramadol, oxycodone, hydrocodone) due
to normal formation of the active metabolites. |
Continue to follow
label recommended dosing. |
Ultra-Rapid Metabolizer
(e.g.,
*2|*2 XN, *1|*1 XN)
|
CYP2D6 UMs may experience
enhanced analgesic effects from certain opioids (e.g., codeine,
tramadol, oxycodone, hydrocodone) and an increased risk for toxicities
due to increased production of the active metabolites. |
Select
alternate drug or monitor closely for adverse drug events (e.g., nausea,
vomiting, constipation, respiratory depression, confusion, urinary
retention). |