Study |
Summary |
Conclusions |
Hakimeh Sadeghian et al.69
|
Prospective study, CABG
plus MV replacement or MV repair were performed in 49 patients with
coronary heart disease complicated with moderate to severe IMR.
The average follow-up period was
18.89±2.1 months. |
The early mortality of the repair group was higher
than that of the replacement group. |
Michael A. Acker et al.64
|
Prospective study, in 251
patients with severe IMR, MV repair or chordal-sparing replacement was
performed. The primary end point was the left ventricular end-systolic
volume index (LVESVI) at 12 months. |
The moderate or severe recurrence
rate of mitral regurgitation in the repair group was higher than that in
the replacement group at 12 months. Replacement provided a more lasting
correction of mitral regurgitation. |
Ahmet Rüçhan Akar et al.61
|
Retrospective study, 146
patients underwent MV surgery from January, 2004 to January, 2009. The
average follow-up time was 586±413 days. |
MV repair is associated with
acceptable surgical mortality, satisfactory medium term survival and
better conserve of LV function. |
Carlo Fino et al.62
|
Retrospective
study, 121 patients with significant chronic
IMR, who
underwent MV repair (n=62) or MV replacement (n=59), between 2005 and
2011. A resting echocardiogram and a 6-minute walking test were taken
preoperatively and repeated at 41±16.5 months.
|
For chronic IMR,
MV replacement versus MV repair
was
associated with better postoperative exercise
hemodynamic performance and long-term functional
ability.
|
Zhibing Qiu et al.65
|
Retrospective study, 218
patients underwent either MV repair (n=112) or MV replacement (n=106).
Intraoperative echocardiography and
follow-up. |
For most severe IMR patients with LV dysfunction, MV repair
is preferred. However, for severe IMR patients with LV dysfunction, the
long-term benefit of MV repair is not as good as MV
replacement. |
A. Marc Gillinov et
al.63
|
Retrospective study, 482 patients
with IMR underwent either valve repair (n = 397) or valve replacement (n
= 85) from 1985 through 1997. |
Most IMR patients benefited from MV
repair. Survival rates after repair and replacement were similar in the
most complex, high-risk settings. |
Simon Maltais et al.71
|
Retrospective study, 387
patients underwent combined CABG and MV surgery, MV repair in 302 (78%)
and MV replacement in 85 (22%) patients from 1993 to 2007. |
The
survival rate after combined operation was compromised and mostly
influenced by the related factors of patients’ condition during
operation. The specifics of MV repair and replacement did not seem to
affect survival. |
Christos G et al.66
|
Prospective study, 251 patients
with severe IMR underwent MV repair (n=126) or MV replacement (n=125).
The LVESVI was measured at 1 and 2
years post-operation. |
MV repair was associated with a significantly
higher incidence of moderate or severe recurrent MR and heart
failure. |
Roberto Lorusso et al.67
|
Retrospective study, from
1996 to 2011, 1006 patients with chronic IMR and LV dysfunction
underwent surgery in 13 Italian institutions. 298 (29.6%) patients
received MV replacement and 708 (70.4%) patients received MV repair.
Intraoperative echocardiography and follow-up. |
For patients with
chronic IMR and impaired LV function, MV replacement is an appropriate
choice. The rate of valvular related complications was comparable and
reoperation was not required. |
Antonio Lio et al.70
|
Retrospective study, from July
2002 to February 2011, 126 patients with IMR and LVEF <40%
underwent MV repair (98,78%) or MV replacement (28,22%). |
In CABG
patients with IMR and depressed LVEF, MV repair was not superior to MV
replacement in terms of early mortality and mid-term survival
rate. |
D Goldstein et al.68
|
Prospective study, 251 patients
with severe IMR underwent MV repair
or chordal-sparing replacement. The primary end point was the LVESVI at
2 years. |
Mitral regurgitation had a higher recurrence rate in the
repair group, leading to more heart failures-related adverse events and
cardiovascular admissions. |
V Shumavets et al.72
|
Retrospective study, from 2000
to 2012, 870 patients with coronary artery diseases and significant IMR
underwent CABG+MV repair (n=787) or CABG+MV replacement (n=83). |
For
patients with severe ischemic LV injury, MV replacement and repair did
not seem to affect survival, which is largely dependent on the factors
related to the patient’s condition during surgery. |