3.3 Tympanic membrane atrophy thinning
Five patients in the ITD group developed tympanic membrane atrophy
thinning. However, no tympanic membrane atrophy thinning was observed in
ITL group which made a significant difference compared with ITD group (p
= 0.018). We made a detailed observation of tympanic membrane atrophy
thinning through ear endoscopy and found the lesions were all located at
the puncture site of the tympanic membrane in the anterior and lower
quadrant of the tympanic membrane. Moreover, the tympanic membrane
showed increased transparency, more shiny and looked thinner, and local
capillary dilatation was visible(Figure 1a showed a patient with
tympanic membrane atrophy thinning after ITD , Figure 1b showed the
patient‘s normal tympanic membrane on the right side).Among the 5
patients, 2were in the ITD1 group and the remaining 3 were in the ITD2
group. There was no significant difference in incidence between patients
who used 5mg/ml of dexamethasone and those who used 2mg/ml. No
perforation of tympanic membrane or fungal or bacterial infection
occurred in these cases during treatment.