5 CONCLUSION
The findings presented in the meta-analysis have important implications worldwide, as many countries still struggle with COVID-19, and hotspots put children at risk for infection. More research into the pathophysiology of multisystem inflammatory syndrome is needed to understand how it differs from that of Kawasaki disease. It could also begin to provide an idea of why some children experience shock and hypotension, while others have less acute complications. Also, a comparison of relative rates of coronary artery aneurysms in multisystem inflammatory syndrome versus Kawasaki disease would help medical decision making.
Although multisystem inflammatory syndrome still appears to be a rare occurrence in COVID-19 positive children, it has become clear that the Kawasaki-like disease requires aggressive medical management with a multidisciplinary team and close, long-term follow up. Recognizing the atypical presentation of the multisystem inflammatory syndrome, monitoring patients for cardiac and renal decompensation, and early interventions to treat the exaggerated immune response in these patients is critical to prevent further morbidity.