Tyrosine kinase inhibitors are the standard treatment for Chronic Myeloid Leukemia. They have significantly improved the response rate and global survival in the long term for CML patients, but also added relevant and diverse toxicity. The authors report a clinical case of ocular toxicity connected to the TKIs.

In spite of existing profuse information regarding hemorrhagic complications of hemophilia, literature is scarce towards the presence of cancer in hemophilia, especially in pediatric patients. There are still many uncertainties concerning these patients’ diagnosis and workup. We report here a rare case of two severe aggressive diseases (neuroblastoma and hemophilia A [HA]) concomitantly present in the same pediatric patient. We highlight that the diagnosis of severe HA did not have a negative impact on the patient’s oncologic course. This case also illustrates the significance of the enriching cooperation among different specialties and hospitals when caring for the same patient.