INTRODUCTION
The coronavirus disease 2019 (COVID-19) is a new emerging infectious disease reported in December 2019 to the World Health Organization (WHO) by the Chinese health authorities as a new outbreak of pneumonia-like cases in Wuhan, China [1,2]. The etiologic agent is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has turned into a pandemic, up until June 19, 2020, there were 8.24 million confirmed cases and 445,535 deaths worldwide [4].
Pediatric patients represent approximately 2.4% of the overall confirmed cases [5]. Illness severity spectrum in children is classified as asymptomatic, mild, moderate, severe and critical disease [6], in contrast, adult clinical classification does not include moderate disease [7,8].  Nevertheless, illness severity among children is thought to be mainly a mild disease [7,9], various studies have reported severe and critical cases as well as fatal outcomes [10-12] whereas an important proportion of children cases are asymptomatic [13].
The spectrum of disease in pediatric patients has a very heterogeneous behavior unlike adults, mostly of patients develop asymptomatic and mild disease, where fever, cough and gastrointestinal symptoms predominate, but can also develop severe disease, requiring hospitalization and even mechanical ventilation, less frequently compared to adults (<7%), recently Multi-systemic Inflammatory Syndrome related to SARS-CoV-2 infection has been described how a severe disease in children. [7, 14, 15]
COVID-19 has a different behavior between age groups regarding epidemiological and clinical characteristics, therefore this study aims to provide a qualitative and quantitative analysis to summarize the evidence available in the literature, about epidemiology, illness severity and clinical features among children.