2.9 Bioinformatics database
The proteins were classfied into three categories, biological process, cellular compartment and molecular function, by gene ontology annotation derived from the NCBI database (www.http: //www.ebi.ac.uk/GOA/). Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to annotate protein pathway. Gene lists were analyzed using the STRING database to identify the predicted interactions of proteins.