Fig. 8. Kinetics of riluzole in comparison to other sodium channel inhibitor compounds.
Calculated binding and unbinding rates of riluzole to 9 sodium channel inhibitor compounds. The figure was re-plotted from El-Bizri et al., (2018)., and supplemented with our data with riluzole, in which case we calculated binding and unbinding rates for both the fast and the slow recovery processes. (AMD –amiodarone; ELEC – eleclazine; FLC – flecainide; LID – lidocaine; MEX – mexiletine; PRF – propafenone; QUI – quinidine; RIL – riluzole).