Estimate heritability according to the prevalence of asthma
We determined the proportion of relative phenotypic variance explained according to the pruned SNPs, \(h_{\text{SNP}}^{2}\). In Figure E4, we calculate \(h_{\text{SNP}}^{2}\) using two different scales, the liability scale and the observed 0-1 scale. On the observed 0-1 scale,\(h_{\text{SNP}}^{2}\ \)varied from 6% to 20% with a disease prevalence ranging from 3% to 10%. Considering a prevalence of 3.9%22, \(h_{\text{SNP}}^{2}\) was 8% (42.6% on the liability scale).