RNA expression imputation with PrediXcan and their
association with asthma
We imputed the RNA expression levels of genes on chromosome 6 for whole
blood and lung tissue using PrediXcan20. This allows
subject-level genes expression prediction for 48 human tissues with
Genotype-Tissue Expression (GTEx) V7 data. Subsequently, linear
regression was used to determine whether the predicted RNA expression is
associated with asthma status. For linear regression, the top 20 PC
scores, age and sex were included as covariates.