A nationwide survey of late effects in survivors of juvenile
myelomonocytic leukemia in Japan
Abstract
We conducted a cross-sectional study using a questionnaire to explore
the late effects in survivors of juvenile myelomonocytic leukemia
(JMML). The attending pediatric hematologist oncologists completed the
questionnaires. All survivors (N=30) had undergone allogeneic
hematopoietic stem cell transplantation. Approximately 83% survivors
showed more than one late effect. The identified late effects included
endocrine, dental, skin, ophthalmologic, musculoskeletal, pulmonary,
neurocognitive, and cardiovascular dysfunction. The prevalence of short
stature and cardiovascular and kidney dysfunction was significantly
elevated among survivors aged ≥18 years. Therefore, a multidisciplinary
follow-up system for survivors of JMML is crucial.