Main findings:
This RCT showed that folic acid gave greater benefit in reducing the Hot
Flush Score in postmenopausal women when compared with placebo. However,
the difference between the two groups did not reach statistical
significance. There was no statistically significant difference in the
secondary outcome measures except in the total and emotional Utian QoL
scores at week 8 where a significant improvement was found in the folic
acid group. However; this difference disappeared at week 12. This
finding was not replicated in a multilevel mixed-effects model analysis.