Conclusion:
This rigorously conducted RCT
showed that folic acid has greater benefit in reducing Hot Flush Score
in postmenopausal women when compared with placebo. However; the
difference between groups did not reach statistical significance. While
the study was unable to demonstrate an unequivocal benefit, folic acid
supplementation represents a cheap, safe and well-tolerated alternative
to conventional HRT, and it remains a potential option for those who are
not able to take HRT such as breast cancer survivors. Definitive
evidence of benefit would however require a larger study.