loading page

RELATIONSHIP BETWEEN COFFEE CONSUMPTION, SLEEP DURATION AND SMOKING STATUS WITH ELASTOGRAPHIC PARAMETERS OF LIVER STEATOSIS AND FIBROSIS; CONTROLLED ATTENUATION PARAMETER AND LIVER STIFFNESS MEASUREMENTS
  • +7
  • Ivana Mikolasevic,
  • Viktor Domislovic,
  • Tajana Filipec Kanizaj,
  • Delfa Radic-Kristo,
  • Zeljko Krznaric,
  • Toni Juric,
  • Mia Klapan,
  • Nadija Skenderevic,
  • Andjela Lukic,
  • Davor Stimac
Ivana Mikolasevic
UHC Rijeka

Corresponding Author:ivana.mikolasevic@gmail.com

Author Profile
Viktor Domislovic
Author Profile
Tajana Filipec Kanizaj
Author Profile
Delfa Radic-Kristo
Author Profile
Zeljko Krznaric
Author Profile
Toni Juric
School of Medicine Rijeka
Author Profile
Mia Klapan
School of Medicine Rijeka
Author Profile
Nadija Skenderevic
Author Profile
Andjela Lukic
School of Medicine Rijeka
Author Profile
Davor Stimac
Author Profile

Abstract

Aim: our aim was to explore the association between life habits and the controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) as the surrogate markers of liver steatosis and fibrosis in a large cohort of nonalcoholic fatty liver disease (NAFLD) patients. Methods: In this prospective, cross-sectional study we had analyzed 1998 patients with diagnosed NAFLD. Sleeping duration was categorized in three groups: short (S) (<6h), moderate (M) (6-8h) and long (L) (>8h) sleep duration. Coffee drinking was categorized into no (0), moderate (1–2) and frequent (≥3) consumption (in cups/day). Smoking was categorized as yes vs. no. Results: Frequent coffee consumers had the lowest prevalence of obesity, hypertension, dyslipidemia, and diabetes. Furthermore, coffee non-consumers had highest values of hepatic enzymes, CAP and LSM. Moderate sleep duration was associated with lower values of CAP and LSM. Coffee consumption was associated with lower CAP in all the multivariate models (CAP unadjusted and model 1,2 and 3), with largest effect in most frequent coffee consumers (≥3, model 3). Also, most frequent coffee consumers were associated with lower LSM in unadjusted model, model 1 and 2, while this was not the case for model 3 and those who consumed 1-2 cups of coffee per day. Reduced sleeping was confirmed as risk factor for elevated CAP in most of the models (unadjusted and model 1 and 2). Also, negative association of LSM was also confirmed in unadjusted model and model 2. Patients which slept 6-8 hours per day were mostly associated with lower CAP and LSM. Smoking did not affect CAP or LSM values. Conclusion: Coffee consumption has beneficial effect on CAP and LSM and this effect is dose dependent since and independent of a variety of relevant confounders. We have shown that moderate sleep duration has also beneficial effect on CAP and LSM.
21 Jul 2020Submitted to International Journal of Clinical Practice
22 Jul 2020Submission Checks Completed
22 Jul 2020Assigned to Editor
26 Jul 2020Reviewer(s) Assigned
10 Aug 2020Review(s) Completed, Editorial Evaluation Pending
27 Sep 20201st Revision Received
28 Sep 2020Submission Checks Completed
28 Sep 2020Assigned to Editor
28 Sep 2020Reviewer(s) Assigned
01 Oct 2020Review(s) Completed, Editorial Evaluation Pending
05 Oct 2020Editorial Decision: Accept
Mar 2021Published in International Journal of Clinical Practice volume 75 issue 3. 10.1111/ijcp.13770