Von Recklinghausen's disease is characterized by skin pigmentation, multiple neurofibromatosis, and osseous changes. In the management of anesthesia, a variety of pathologies need to be taken into account. This case describes the perioperative management of a patient with Recklinghausen's disease suspected difficulty in airway management.

22 q 11.2 deletion syndrome is a genetic disease associated with a high rate of various psychiatric disorders in addition to multiple physical diseases. This case report suggested that a multidisciplinary team approach is important for perioperative management of patient with 22 q 11.2 deletion syndrome.

von Willebrand disease is a hereditary disease associated with a tendency to bleed and it is important to reduce the possibility of bleeding in a procedure. This case describes the use of a hemostatic factor, Factor VIII concentrate (Confact F®), during a dental procedure involving teeth extraction and implant placement.

Freeman-Sheldon syndrome (FSS) is characterized by multiple joint contractures, characteristic facial features, such as microtia, defects of the hands and feet, such as clubfoot, and skeletal malformations. This report illustrates the case of a patient with FSS who was managed under local anesthesia with intravenous sedation for oral surgery.

Thyroglossal duct on the dorsum of the tongue in the pediatric patient can cause a difficult airway due to the large mass and risk of airway obstruction associated with a swollen tongue after surgery.