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Convalescent plasma for pediatric patients with COVID-19 associated acute respiratory distress syndrome
  • +26
  • Caroline Diorio,
  • Elizabeth Anderson,
  • Kevin McNerney,
  • Eileen Goodwin,
  • Julie Chase,
  • Marcus Bolton,
  • Claudia Arevalo,
  • Madison Weirick,
  • Sigrid Gouma,
  • Laura Vella,
  • Sarah Henrickson,
  • Kathleen Chiotos,
  • Julie Fitzgerald,
  • Todd Kilbaugh,
  • Audrey Odom John,
  • Allison Blatz,
  • Michele Lambert,
  • Kathleen Sullivan,
  • Margaret Tartaglione,
  • Danielle Zambrano,
  • Meghan Martin,
  • Jessica Lee,
  • Pampee Young,
  • David Friedman,
  • Deborah Sesok-Pizzini,
  • Scott Hensley,
  • Edward Behrens,
  • Hamid Bassiri,
  • David Teachey
Caroline Diorio
The Children's Hospital of Philadelphia

Corresponding Author:diorioc@email.chop.edu

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Elizabeth Anderson
University of Pennsylvania Perelman School of Medicine
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Kevin McNerney
The Children's Hospital of Philadelphia
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Eileen Goodwin
University of Pennsylvania Perelman School of Medicine
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Julie Chase
The Children's Hospital of Philadelphia
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Marcus Bolton
University of Pennsylvania Perelman School of Medicine
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Claudia Arevalo
University of Pennsylvania Perelman School of Medicine
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Madison Weirick
University of Pennsylvania Perelman School of Medicine
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Sigrid Gouma
University of Pennsylvania Perelman School of Medicine
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Laura Vella
The Children's Hospital of Philadelphia
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Sarah Henrickson
The Children's Hospital of Philadelphia
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Kathleen Chiotos
The Children's Hospital of Philadelphia
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Julie Fitzgerald
The Children's Hospital of Philadelphia
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Todd Kilbaugh
The Children's Hospital of Philadelphia
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Audrey Odom John
The Children's Hospital of Philadelphia
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Allison Blatz
The Children's Hospital of Philadelphia
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Michele Lambert
The Children's Hospital of Philadelphia
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Kathleen Sullivan
The Children's Hospital of Philadelphia
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Margaret Tartaglione
The Children's Hospital of Philadelphia
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Danielle Zambrano
The Children's Hospital of Philadelphia
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Meghan Martin
The Children's Hospital of Philadelphia
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Jessica Lee
The Children's Hospital of Philadelphia
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Pampee Young
American Red Cross
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David Friedman
The Children's Hospital of Philadelphia
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Deborah Sesok-Pizzini
The Children's Hospital of Philadelphia
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Scott Hensley
University of Pennsylvania Perelman School of Medicine
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Edward Behrens
The Children's Hospital of Philadelphia
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Hamid Bassiri
The Children's Hospital of Philadelphia
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David Teachey
The Children's Hospital of Philadelphia
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Abstract

There are no proven safe and effective therapies for children who develop life-threatening complications of SARS-CoV-2. Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2 but has theoretical risks. We report on the first use of CP in children with life-threatening COVID-19, providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed.
15 Jul 2020Submission Checks Completed
15 Jul 2020Assigned to Editor
15 Jul 2020Submitted to Pediatric Blood & Cancer
16 Jul 2020Reviewer(s) Assigned
11 Aug 2020Review(s) Completed, Editorial Evaluation Pending
13 Aug 2020Editorial Decision: Revise Minor
23 Aug 2020Submission Checks Completed
23 Aug 2020Assigned to Editor
23 Aug 20201st Revision Received
24 Aug 2020Review(s) Completed, Editorial Evaluation Pending
24 Aug 2020Editorial Decision: Accept