Potential implication of PARP inhibitors in Covid-19
Several evidences have supported the involvement of PARP1 in oxidative stress mediated response, inflammation and various diseases. PARP-1 mediated inflammatory response caused by bacteria and other pathogenic agents like parasite and fungi has been elucidated. PARP1 is also known to regulate cytokine production and the string analysis also depict direct PARP1 interaction with some cytokines and indirect with few other cytokines known to be involved in Covid-19 (Fig 1). Although there are reports of PARP1 regulation of virus-host interaction and virus infection, but detailed mechanistic studies are required as PARP1 involvement in virus mediated inflammation is not elucidated fully. PARP1 mediated inflammation during fibrosis, ischaemia and stroke and its relationship with viruses, inspired us to think about probability of role of PARP1 in SARS-CoV-2 mediated inflammation. Further work is required to identify the link between SARS-CoV-2 virus infection and PARP1 mediated inflammation.