Reference values of impulse oscillometry (IOS) for healthy Chinese
children aged 4-18 years
Abstract
Objective: To establish the predicted value of lung function determined
by impulse oscillometry (IOS) in children (4~17 years
old) in China. Methods: A total of 6270 healthy children aged 4 to 17 in
Shanghai were included. The Master Screen IOS pulmonary function device
(Jaeger Co, Germany) was used to detect the respiratory total impedance
(Zrs), response frequency (Fres), viscosity resistance (Rrs) and elastic
resistance (Xrs) at various oscillation frequencies, and the indexes
above were analyzed. The stepwise multivariate regression was used to
establish the regression equation of related parameters of IOS in
different genders. Results The median age of 6270 children (3345 boys
and 2925 girls) was 10 years, ranging from 4 to 17 years. The
differences in the main IOS parameters between different age and height
groups are statistically significant regardless of sex
(P<0.05). The values of Z5, R5, R20, and Fres decreased with
the increase of age and height, while X5 increased with the increase of
age and height. The stepwise multivariate regression analysis showed
that IOS parameters were related to height, age, and weight, and most
IOS parameters were most closely related to height (the absolute value
of regression coefficient was the largest). Conclusions: The study
revealed the normal predicted value of pulmonary function by IOS in
healthy children in China. In the evaluation of the results of the lung
function measurements, the use of this predicted value equation is more
in line with the characteristics of Chinese children than that of
foreign countries. Key words: impulse oscillometry; respiratory function
test; normal predicted value; child