Population
This study comprised consecutive patients treated at the Heart Institute of Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo with inherited CChs (LQTS, BrS or CPVT) and ICD receiving optimal drug therapy. The inclusion criteria were patients having dental caries, unsatisfactory restorations in the mandible and restorative dental treatment indication. The exclusion criteria were the following: allergy to lidocaine, sodium metabisulfite, or methylparaben; patients with recurrent syncope or sustained arrhythmias documented for at least 3 months, including appropriate and innappropriate ICD shocks; patients who had received epinephrine in the previous 24 hours; and patients with a body weight <20 kg (a child ≅ 6 years old because of the maximum safe dose of lidocaine, 4.4 mg/kg, used in 2 anesthetic cartridges 23).
All patients were included after reading and signing the written informed consent form. This study was approved by the Ethics Committee of Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo (18221913.5.0000.0068) and was previously registered at ClinicalTrials.gov (ID: NCT03182777) and can be accessed at https://clinicaltrials.gov/ct2/show/NCT03182777?term=NCT03182777&rank=1