Publication bias
Based on the visual inspection of the funnel plots and the Begg’s test, there was asymmetry among studies reporting reoperation for bleeding and the test was significant (p = 0.0012; Supplementary Figure 3-A). There was no publication bias among studies reporting the number of patients with postoperative bleeding (p = 0.4624; Supplementary Figure 3-B). Moreover, publication bias was detected among studies reporting in-hospital mortality (p = 0.0153; Supplementary Figure 3-C).