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KMT2A-rearranged diffuse large B-cell lymphoma in a child: a case report and molecular characterization
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  • Shota Kato,
  • Yasuo Kubota,
  • Masahiro Sekiguchi,
  • Kentaro Watanabe,
  • Aya Shinozaki-Ushiku,
  • Junko Takita,
  • Mitsuteru Hiwatari
Shota Kato
The University of Tokyo

Corresponding Author:shikato-tky@umin.ac.jp

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Yasuo Kubota
The University of Tokyo
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Masahiro Sekiguchi
The University of Tokyo
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Kentaro Watanabe
The University of Tokyo
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Aya Shinozaki-Ushiku
The University of Tokyo
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Junko Takita
The University of Tokyo
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Mitsuteru Hiwatari
The University of Tokyo
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Abstract

A 19-month-old female with a right temporal bone tumor was diagnosed with diffuse large B-cell lymphoma by tumor biopsy. Leukemic conversion occurred after chemotherapy for mature B-cell lymphoma. Additional chemotherapy was unsuccessful and resulted in death of the patient owing to disease progression. We detected the KMT2A-MLLT3 fused transcript in the bone marrow of the patient with primary and recurrent cancer. RNA sequencing of the bone marrow with recurrent cancer showed similarities with KMT2A-rearranged leukemia, such as overexpression of MEIS1 and MEF2C, which was attributable to the aggressive course.